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Tocris AGI 5198

Potent and selective inhibitor of mutant isocitrate dehydrogenase 1 (mIDH1)

Manufacturer:  Tocris 7087/25

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Catalog No. 70-872-5

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AGI 5198 is a potent and selective inhibitor of mutant isocitrate dehydrogenase 1 (mIDH1; IC50 = 70 nM). Selective for mIDH1 over wild-type IDH1 and IDH2. Inhibits production of oncometabolite D-2 hydroxyglutarate. Attenuates growth of glioma cells containing mIDH1, but not wild-type IDH1, in vitro and in vivo. Also inhibits growth of fibrosarcoma and chondrosarcoma cells bearing mIDH1.


N-[2-(Cyclohexylamino)-1-(2-methylphenyl)-2-oxoethyl]-N-(3-fluorophenyl)-2-methyl-1 H-Imidazole-1-acetamide
Dehydrogenase Inhibitors
25 mg
Safety and Handling

Safety and Handling

Recommended Storage : Store at -20°C

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