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Tocris Bioscience™ AGI 5198
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Catalog No. 708725
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25 mg
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70-872-5 25 mg
70-875 5 mg
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Catalog No. 70-872-5 Supplier Tocris Bioscience™ Supplier No. 7087/25
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Description

Potent and selective inhibitor of mutant isocitrate dehydrogenase 1 (mIDH1)

AGI 5198 is a potent and selective inhibitor of mutant isocitrate dehydrogenase 1 (mIDH1; IC50 = 70 nM). Selective for mIDH1 over wild-type IDH1 and IDH2. Inhibits production of oncometabolite D-2 hydroxyglutarate. Attenuates growth of glioma cells containing mIDH1, but not wild-type IDH1, in vitro and in vivo. Also inhibits growth of fibrosarcoma and chondrosarcoma cells bearing mIDH1.

Specifications

Chemical Name or Material N-[2-(Cyclohexylamino)-1-(2-methylphenyl)-2-oxoethyl]-N-(3-fluorophenyl)-2-methyl-1 H-Imidazole-1-acetamide
CAS 1355326-35-0
Quantity 25 mg
Target Dehydrogenase Inhibitors
Molecular Formula C27H31FN4O2
Purity 0.98
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