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AGK 2, Tocris Bioscience™

Catalog No. 323350
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Quantity:
10 mg
50 mg
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This item is not returnable. View return policy

Description

Selective SIRT2 inhibitor

Selective inhibitor of SIRT2 (IC50 = 3.5 μM). Displays no activity at SIRT1 and SIRT3 at concentrations up to 40 μM. Reduces α-synuclein-mediated toxicity in in vitro and in vivo models of Parkinson's disease.

Chemical Identifiers

CAS 304896-28-4
Molecular Formula C23H13Cl2N3O2
Molecular Weight (g/mol) 434.28
MDL Number MFCD01909444
InChI Key SVENPFFEMUOOGK-UHFFFAOYSA-N
PubChem CID 2130404
IUPAC Name 2-cyano-3-[5-(2,5-dichlorophenyl)furan-2-yl]-N-(quinolin-5-yl)prop-2-enamide
SMILES ClC1=CC(C2=CC=C(O2)C=C(C#N)C(=O)NC2=C3C=CC=NC3=CC=C2)=C(Cl)C=C1

Specifications

Quantity 50 mg
Synonym agk2, agk-2, agk 2, unii-ddf0l8606a, sirtuin 2 inhibitor, sirt2 inhibitor, agk2, 2-cyano-3-5-2,5-dichlorophenyl-2-furanyl-n-5-quinolinyl-2-propenamide, e-2-cyano-3-5-2,5-dichlorophenyl furan-2-yl-n-quinolin-5-ylprop-2-enamide, 2-cyano-3-5-2,5-dichlorophenyl furan-2-yl-n-quinolin-5-yl acrylamide
Formula Weight 434.27
Percent Purity >98%
Chemical Name or Material AGK 2

Safety and Handling

Recommended Storage Store at +4°C
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