Ago1/2/3 Monoclonal Antibody (2A8), Active Motif™

Catalog No.	Quantity
50-199-2980	10 μg
50-199-2979	100 μg

Catalog No. 50-199-2980 Supplier Active Motif Supplier No. 39938

Description

Mouse Monoclonal Antibody

The Argonaute family of proteins play roles in RNA interference and in short-interfering-RNA-mediated gene silencing. Small interfering RNAs (siRNAs) have gained much attention for their powerful ability to suppress gene expression. Introduction of double-stranded RNA (dsRNA), that are homologues in sequence to a gene, has proven to suppress that gene's expression through a process known as RNA interference (RNAi); this process post-transcriptionally silences a gene through mRNA inhibition or degradation. Both biochemical and genetic studies have led to the identification of two, conserved gene families that are universal components of the interference process. These are the Dicer family, which is comprised of members of the Ribonuclease III family of enzymes, and the Argonaute gene family. Argonaute proteins addition to their role in RNAi process, may also influence development, such as, stem cell fate determination.

Specifications

• Antigen: Ago1/2/3
• Applications: Immunoprecipitation
• Classification: Monoclonal
• Clone: 2A8
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: 70mM tris with 0.07mM EDTA, 105mM NaCl, 30% glycerol, 31mM glycine and 0.035% sodium azide; pH 8
• Gene: AGO2
• Gene Accession No.: Q9H9G7, Q9UKV8, Q9UL18
• Gene Symbols: AGO1, AGO2, AGO3
• Host Species: Mouse
• Immunogen: This Ago1/2/3 antibody was raised against a recombinant protein corresponding to amino acids 47-859 of human Ago2.
• Purification Method: Protein G
• Quantity: 10 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 192669, 26523, 27161
• Target Species: Human
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG