Ago3 Monoclonal Antibody (4B1-F6), Active Motif™

Mouse Monoclonal Antibody

Supplier:  Active Motif 39788

Catalog No. 50-199-2853

Description

AGO3 (protein argonaute-3) is required to RNA-mediated gene silencing (RNAi). It binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. AGO3 is proposed to be involved in stabilization of small RNA derivates (riRNA) derived from processed RNA polymerase III-transcribed Alu repeats containing a DR2 retinoic acid response element (RARE) in stem cells and in the subsequent riRNA-dependent degradation of a subset of RNA polymerase II-transcribed coding mRNAs by recruiting a mRNA decapping complex involving EDC4.

Specifications

• Antigen: Ago3
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: 70mM tris with 0.07mM EDTA, 105mM NaCl, 30% glycerol, 31mM glycine and 0.035% sodium azide; pH 8
• Gene Accession No.: Q9H9G7
• Gene Symbols: AGO3
• Immunogen: This Ago3 (Argonaute 3) antibody was raised against a recombinant protein corresponding to amino acids 1-175 of human Ago3.
• Quantity: 10 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a

• Applications: ChIP Assay, Immunocytochemistry, Immunofluorescence, Immunoprecipitation
• Clone: 4B1-F6
• Conjugate: Unconjugated
• Gene: AGO3
• Gene Alias: AGO3; argonaute 3; argonaute 3, RISC catalytic component; Argonaute RISC catalytic component 3; argonaute RISC catalytic subunit 3; Argonaute3; AW048688; BOS_3617; C130014L07Rik; eIF2C 3; eIF-2C 3; EIF2C1; EIF2C3; Eukaryotic translation initiation factor 2C 3; eukaryotic translation initiation factor 2C, 1; eukaryotic translation initiation factor 2C, 3; hAgo3; mAgo3; Piwi/argonaute family protein meIF2C3; Protein argonaute-3
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 192669
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid