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Invitrogen™ Agrin Monoclonal Antibody (Agr 33)
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Catalog No. PIMA120378
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100 μg
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Catalog No. Quantity
PIMA120378 100 μg
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Catalog No. PIMA120378 Supplier Invitrogen™ Supplier No. MA120378
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Description

Mouse Monoclonal Antibody

MA1-20378 detects agrin in mouse and rat samples.

Agrin is a molecule that resides in the basal lamina of muscle cells and directs key events in post synaptic differentiation. Most notably, Agrin is responsible for the clustering of acetylcholine receptors (AChRs) on the cell surface and their localization to the neuromuscular junction. Several Agrin variants have been identified which arise from alternative mRNA splicings. Agrin splice forms having inserts at two sites in the carboxy terminus designated 'y' and 'z' display a high affinity for AChRs, while splice forms lacking these inserts associate with AChRs weakly. Muscle alpha-dystroglycan has been postulated to be the receptor for the clustering activity of agrin; however, this is a point of contention. Tyrosine phosphorylation has been implicated as a required early step in AChR aggregation. Interestingly, a unique receptor tyrosine kinase, designated MuSK, has been discovered that interacts with Agrin and is specifically localized to developing muscle.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Agrin
Applications Immunohistochemistry, Western Blot, Immunocytochemistry
Classification Monoclonal
Clone Agr 33
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.1mM PMSF, 50% glycerol and no preservative, pH 7.2
Gene Agrn
Gene Accession No. A2ASQ1, P25304
Gene Alias AGR; Agrin; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 22 kDa fragment; Agrin C-terminal 90 kDa fragment; Agrin N-terminal 110 kDa subunit; agrin proteoglycan; Agrn; C22; C90; CMS8; CMSPPD; nmf380; RP23-139J18.2
Gene Symbols Agrn
Host Species Mouse
Immunogen Recombinant rat agrin, C-terminal construct.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 11603, 25592
Target Species Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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