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Invitrogen™ Agrin Polyclonal Antibody
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Catalog No. PIPA559064
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100 μL
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PIPA559064 100 μL
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Catalog No. PIPA559064 Supplier Invitrogen™ Supplier No. PA559064
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: RYLKGKDLVA RESLLDGGNK VVISGFGDPL ICDNQVSTGD TRIFFVNPAP PYLWPAHKNE LMLNSSLMRI TLRNLEEVEF CVEDKPGTHF TPVPPTPPDA CRG Highest antigen sequence identity to the following orthologs: Mouse - 91%, Rat - 46%.

Agrin is a molecule that resides in the basal lamina of muscle cells and directs key events in post synaptic differentiation. Most notably, Agrin is responsible for the clustering of acetylcholine receptors (AChRs) on the cell surface and their localization to the neuromuscular junction. Several Agrin variants have been identified which arise from alternative mRNA splicings. Agrin splice forms having inserts at two sites in the carboxy terminus designated y and z display a high affinity for AChRs, while splice forms lacking these inserts associate with AChRs weakly. Muscle alpha-dystroglycan has been postulated to be the receptor for the clustering activity of agrin; however, this is a point of contention. Tyrosine phosphorylation has been implicated as a required early step in AChR aggregation. Interestingly, a unique receptor tyrosine kinase, designated MuSK, has been discovered that interacts with Agrin and is specifically localized to developing muscle.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Agrin
Applications Immunohistochemistry (Paraffin), Immunocytochemistry
Classification Polyclonal
Concentration 0.3 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Agrn
Gene Accession No. O00468
Gene Alias AGR; Agrin; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 22 kDa fragment; Agrin C-terminal 90 kDa fragment; Agrin N-terminal 110 kDa subunit; agrin proteoglycan; Agrn; C22; C90; CMS8; CMSPPD; nmf380; RP23-139J18.2
Gene Symbols Agrn
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human Agrin. Recombinant protein control fragment (Product #RP-89940).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 375790
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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