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Invitrogen™ AHNAK Polyclonal Antibody
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Catalog No. PIPA555363
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100 μL
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PIPA555363 100 μL
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Catalog No. PIPA555363 Supplier Invitrogen™ Supplier No. PA555363
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: MKGTKVKTPE MIIQKPKISM QDVDLSLGSP KLKGDIKVSA PGVQGDVKGP QVALKGSRVD IETPNLEGTL TGPRLGSPSG KTGTCRISMS EVDLNVAAPK VKGGVDVTLP RVEGKVKVPE VDVRGPKVDV SA Highest antigen sequence identity to the following orthologs: Mouse - 81%, Rat - 82%.

AHNAK1 (Desmoyokin) is a large (700 kDa) scaffold protein that translocates to the plasma membrane after an increas of extracellular calcium level or upon proteinkinase C activation and regulates extracellular calcium influx mediated by L-type Ca2+ channels. AHNAK1 has been implicated in diverse signal transduction proceses affecting cell differentiation and proliferation. In response to calcium-dependent intercellular contacts AHNAK1 forms multimeric complexes in the plasma membrane, connected with actin and annexin 2/S100A10 assemblies and is thus involved in organization of the plasma membrane architecture. In epithelial cells, AHNAK1 is localized in cytoplasm or is membrane-associated, but in cells of nonepithelial origin AHNAK1 is predominantly nuclear; it has a weak DNA-binding activity and associates with the DNA-ligase IV-XRCC4 complex.
TRUSTED_SUSTAINABILITY

Specifications

Antigen AHNAK
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene AHNAK
Gene Accession No. Q09666
Gene Alias AHNAK; AHNAK 1; AHNAK nucleoprotein; AHNAK nucleoprotein (desmoyokin); AHNAK-related; AHNAKRS; Desmoyokin; DY6; MGC5395; Neuroblast differentiation-associated protein AHNAK; PM227; RGD1308572; UV118
Gene Symbols AHNAK
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human AHNAK. Recombinant protein control fragment (Product #RP-92505).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 79026
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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