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Invitrogen™ AIFM3 Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA520503
Description
A suggested positive control is human brain tissue lysate. PA5-20503 can be used with blocking peptide PEP-0623.
Apoptosis, also known as programmed cell death, plays major roles in development and normal tissue turnover in addition to tumor formation. Recently a protein similar to the apoptosis-inducing factor (AIF) was cloned and designated AIFL (also known as AIFM3). AIFM3 is expressed ubiquitously and is predominantly localized to the inner membranes of mitochondria. Unlike AIF, AIFM3 does not translocate to the nucleus upon induction of apoptosis. However, overexpression of AIFM3, like AIF, induced cytochrome c release from the mitochondria, cleavage of caspase 3, and ultimately apoptosis, indicating AIFM3 induces apoptosis through caspase activation. Multiple isoforms of AIFM3 are known to exist.
Specifications
AIFM3 | |
Polyclonal | |
Unconjugated | |
AIFM3 | |
2810401C16Rik; AI840249; Aifl; AIFM3; apoptosis inducing factor, mitochondria associated 3; apoptosis-inducing factor 3; apoptosis-inducing factor like; apoptosis-inducing factor, mitochondrion-associated 3; apoptosis-inducing factor, mitochondrion-associated, 3; apoptosis-inducing factor-like protein; RGD1306028 | |
Rabbit | |
Antigen Affinity Chromatography | |
RUO | |
150209, 303786, 72168 | |
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C | |
Liquid |
Western Blot | |
1 mg/mL | |
PBS with 0.02% sodium azide | |
Q3TY86, Q96NN9 | |
AIFM3 | |
A 16 amino acid peptide from near the center of human AIFM3. | |
100 μg | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG |
Safety and Handling
WARNING: Cancer - www.P65Warnings.ca.gov
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