Invitrogen™ AIFM3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA520503

Catalog No. PIPA520503

Description

A suggested positive control is human brain tissue lysate. PA5-20503 can be used with blocking peptide PEP-0623.

Apoptosis, also known as programmed cell death, plays major roles in development and normal tissue turnover in addition to tumor formation. Recently a protein similar to the apoptosis-inducing factor (AIF) was cloned and designated AIFL (also known as AIFM3). AIFM3 is expressed ubiquitously and is predominantly localized to the inner membranes of mitochondria. Unlike AIF, AIFM3 does not translocate to the nucleus upon induction of apoptosis. However, overexpression of AIFM3, like AIF, induced cytochrome c release from the mitochondria, cleavage of caspase 3, and ultimately apoptosis, indicating AIFM3 induces apoptosis through caspase activation. Multiple isoforms of AIFM3 are known to exist.

Specifications

• Antigen: AIFM3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: AIFM3
• Gene Alias: 2810401C16Rik; AI840249; Aifl; AIFM3; apoptosis inducing factor, mitochondria associated 3; apoptosis-inducing factor 3; apoptosis-inducing factor like; apoptosis-inducing factor, mitochondrion-associated 3; apoptosis-inducing factor, mitochondrion-associated, 3; apoptosis-inducing factor-like protein; RGD1306028
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 150209, 303786, 72168
• Content And Storage: Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: Q3TY86, Q96NN9
• Gene Symbols: AIFM3
• Immunogen: A 16 amino acid peptide from near the center of human AIFM3.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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