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Invitrogen™ AIFM3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA520503

Catalog No. PIPA520503


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Description

Description

A suggested positive control is human brain tissue lysate. PA5-20503 can be used with blocking peptide PEP-0623.

Apoptosis, also known as programmed cell death, plays major roles in development and normal tissue turnover in addition to tumor formation. Recently a protein similar to the apoptosis-inducing factor (AIF) was cloned and designated AIFL (also known as AIFM3). AIFM3 is expressed ubiquitously and is predominantly localized to the inner membranes of mitochondria. Unlike AIF, AIFM3 does not translocate to the nucleus upon induction of apoptosis. However, overexpression of AIFM3, like AIF, induced cytochrome c release from the mitochondria, cleavage of caspase 3, and ultimately apoptosis, indicating AIFM3 induces apoptosis through caspase activation. Multiple isoforms of AIFM3 are known to exist.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

AIFM3
Polyclonal
Unconjugated
AIFM3
2810401C16Rik; AI840249; Aifl; AIFM3; apoptosis inducing factor, mitochondria associated 3; apoptosis-inducing factor 3; apoptosis-inducing factor like; apoptosis-inducing factor, mitochondrion-associated 3; apoptosis-inducing factor, mitochondrion-associated, 3; apoptosis-inducing factor-like protein; RGD1306028
Rabbit
Antigen Affinity Chromatography
RUO
150209, 303786, 72168
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Liquid
Western Blot
1 mg/mL
PBS with 0.02% sodium azide
Q3TY86, Q96NN9
AIFM3
A 16 amino acid peptide from near the center of human AIFM3.
100 μg
Primary
Human, Mouse, Rat
Antibody
IgG
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