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Invitrogen™ AIFM3 Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA597129
Description
Immunogen sequence: MGGCFSKPKP VELKIEVVLP EKERGKEELS ASGKGSPRAY QGNGTARHFH TEERLSTPHP YPSPQDCVEA AVCHVKDLEN GQMREVELGW GKVLLVKDNG EFHALGHKCP HYGAPLVKGV LSRGRVRCPW HGACFNISTG DLEDFPGLDS LHKFQVKIEK EKVYVRASKQ ALQLQRRTKV MAKCISPSAG YSSSTNVLIV; Positive Samples: THP-1, HeLa; Cellular Location: Mitochondrion.
Apoptosis, also known as programmed cell death, plays major roles in development and normal tissue turnover in addition to tumor formation. Recently a protein similar to the apoptosis-inducing factor (AIF) was cloned and designated AIFL (also known as AIFM3). AIFM3 is expressed ubiquitously and is predominantly localized to the inner membranes of mitochondria. Unlike AIF, AIFM3 does not translocate to the nucleus upon induction of apoptosis. However, overexpression of AIFM3, like AIF, induced cytochrome c release from the mitochondria, cleavage of caspase 3, and ultimately apoptosis, indicating AIFM3 induces apoptosis through caspase activation. Multiple isoforms of AIFM3 are known to exist.
Specifications
AIFM3 | |
Polyclonal | |
Unconjugated | |
AIFM3 | |
2810401C16Rik; AI840249; Aifl; AIFM3; apoptosis inducing factor, mitochondria associated 3; apoptosis-inducing factor 3; apoptosis-inducing factor like; apoptosis-inducing factor, mitochondrion-associated 3; apoptosis-inducing factor, mitochondrion-associated, 3; apoptosis-inducing factor-like protein; RGD1306028 | |
Rabbit | |
Affinity chromatography | |
RUO | |
150209, 303786, 72168 | |
-20°C, Avoid Freeze/Thaw Cycles | |
Liquid |
ELISA, Immunohistochemistry (Paraffin), Western Blot | |
0.74 mg/mL | |
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 | |
Q3TY86, Q96NN9 | |
AIFM3 | |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human AIFM3 (NP_0010180701). | |
100 μL | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG |
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