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AIPL1 Monoclonal Antibody (OTI1B2), TrueMAB™, OriGene
SDP

Mouse Monoclonal Antibody

Supplier:  OriGene TA503572

Encompass_Preferred

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Catalog No. 50-167-4432


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Description

Description

Aipl1 was initially identified as a protein implicated in Leber congenital amaurosis (LCA), an autosomal recessive disorder thought to be caused by the abnormal development of photoreceptors. Aipl1 is a tetratricopeptide repeat protein that is highly homologous to ARA9, a protein involved in the HSP90-mediated nuclear translocation and transactivation of the aryl hydrocarbon receptor. Aipl1 has also been found to function as part of a chaperone heterocomplex, interacting with Hsp90 and Hsp70. Aipl1 also associates with the cell cycle regulator NUB1. It is thought that Aipl1 cooperates with Hsp70 but not Hsp90 to suppress the formation of NUB1 inclusions, and these interactions are necessary in the normal photoreceptor maturation, as mutations that lead to LCA also compromise the interactions with the Hsp chaperones. At least three isoforms of Aipl1 are known to exist.
Specifications

Specifications

AIPL1
Monoclonal
0.47 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Q9NZN9
AIPL1
Full length human recombit protein of human AIPL1 produced in HEK293T cell.
100 μL
Primary
Human
Antibody
IgG1
Flow Cytometry, Immunocytochemistry, Immunofluorescence, Western Blot
OTI1B2
Unconjugated
AIPL1
AIPL2, LCA4
Mouse
Affinity Chromatography
RUO
23746
-20° C, Avoid Freeze/Thaw Cycles
Liquid
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