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Invitrogen™ AIPL1 Monoclonal Antibody (OTI3B4)
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Catalog No. PIMA525721
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100 μL
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Catalog No. Quantity
PIMA525721 100 μL
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Catalog No. PIMA525721 Supplier Invitrogen™ Supplier No. MA525721
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Description

Mouse Monoclonal Antibody

AIPL1 Monoclonal Antibody for Western Blot, ICC/IF, IHC (P), Flow

Aipl1 was initially identified as a protein implicated in Leber congenital amaurosis (LCA), an autosomal recessive disorder thought to be caused by the abnormal development of photoreceptors. Aipl1 is a tetratricopeptide repeat protein that is highly homologous to ARA9, a protein involved in the HSP90-mediated nuclear translocation and transactivation of the aryl hydrocarbon receptor. Aipl1 has also been found to function as part of a chaperone heterocomplex, interacting with Hsp90 and Hsp70. Aipl1 also associates with the cell cycle regulator NUB1. It is thought that Aipl1 cooperates with Hsp70 but not Hsp90 to suppress the formation of NUB1 inclusions, and these interactions are necessary in the normal photoreceptor maturation, as mutations that lead to LCA also compromise the interactions with the Hsp chaperones. At least three isoforms of Aipl1 are known to exist.
TRUSTED_SUSTAINABILITY

Specifications

Antigen AIPL1
Applications Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Monoclonal
Clone OTI3B4
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene AIPL1
Gene Accession No. Q9NZN9
Gene Alias A930007I01Rik; AIPL1; AIPL2; aryl hydrocarbon receptor interacting protein like 1; aryl hydrocarbon receptor interacting protein-like 1; aryl hydrocarbon receptor-interacting protein-like 1; aryl-hydrocarbon interacting protein-like 1; aryl-hydrocarbon-interacting protein-like 1; EGK_08083; LCA4
Gene Symbols AIPL1
Host Species Mouse
Immunogen Full length human recombinant protein of AIPL1 produced in HEK293T cell.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 23746
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG1
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