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Invitrogen™ AIPL1 Polyclonal Antibody
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Catalog No. PIPA520623
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100 μg
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Catalog No. Quantity
PIPA520623 100 μg
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Catalog No. PIPA520623 Supplier Invitrogen™ Supplier No. PA520623
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Description

Rabbit Polyclonal Antibody

A suggested positive control is human brain tissue lysate. PA5-20623 can be used with blocking peptide PEP-0743.

Aipl1 was initially identified as a protein implicated in Leber congenital amaurosis (LCA), an autosomal recessive disorder thought to be caused by the abnormal development of photoreceptors. Aipl1 is a tetratricopeptide repeat protein that is highly homologous to ARA9, a protein involved in the HSP90-mediated nuclear translocation and transactivation of the aryl hydrocarbon receptor. Aipl1 has also been found to function as part of a chaperone heterocomplex, interacting with Hsp90 and Hsp70. Aipl1 also associates with the cell cycle regulator NUB1. It is thought that Aipl1 cooperates with Hsp70 but not Hsp90 to suppress the formation of NUB1 inclusions, and these interactions are necessary in the normal photoreceptor maturation, as mutations that lead to LCA also compromise the interactions with the Hsp chaperones. At least three isoforms of Aipl1 are known to exist.
TRUSTED_SUSTAINABILITY

Specifications

Antigen AIPL1
Applications Immunohistochemistry, Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene AIPL1
Gene Accession No. Q924K1, Q9NZN9
Gene Alias A930007I01Rik; AIPL1; AIPL2; aryl hydrocarbon receptor interacting protein like 1; aryl hydrocarbon receptor interacting protein-like 1; aryl hydrocarbon receptor-interacting protein-like 1; aryl-hydrocarbon interacting protein-like 1; aryl-hydrocarbon-interacting protein-like 1; EGK_08083; LCA4
Gene Symbols AIPL1
Host Species Rabbit
Immunogen A 17 amino acid peptide near the carboxy terminus of the human Aipl1.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 114230, 23746
Target Species Human, Mouse
Content And Storage Maintain refrigerated at 2°C to 8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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