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Invitrogen™ AIPL1 Polyclonal Antibody
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Catalog No. PIPA582924
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PIPA582924 100 μL
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Catalog No. PIPA582924 Supplier Invitrogen™ Supplier No. PA582924
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: AEVWNEAEAK ADLQKVLELE PSMQKAVRRE LRLLENRMAE KQEEERLRCR NMLSQGATQP PAEPPTEPPA QSSTEPPAEP PTAPSAELSA GPPAEPATEP PPSPGHSLQH Highest antigen sequence indentity to the following orthologs: Mouse - 39%, Rat - 39%.

Aipl1 was initially identified as a protein implicated in Leber congenital amaurosis (LCA), an autosomal recessive disorder thought to be caused by the abnormal development of photoreceptors. Aipl1 is a tetratricopeptide repeat protein that is highly homologous to ARA9, a protein involved in the HSP90-mediated nuclear translocation and transactivation of the aryl hydrocarbon receptor. Aipl1 has also been found to function as part of a chaperone heterocomplex, interacting with Hsp90 and Hsp70. Aipl1 also associates with the cell cycle regulator NUB1. It is thought that Aipl1 cooperates with Hsp70 but not Hsp90 to suppress the formation of NUB1 inclusions, and these interactions are necessary in the normal photoreceptor maturation, as mutations that lead to LCA also compromise the interactions with the Hsp chaperones. At least three isoforms of Aipl1 are known to exist.
TRUSTED_SUSTAINABILITY

Specifications

Antigen AIPL1
Applications Immunohistochemistry (Paraffin), Immunocytochemistry
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene AIPL1
Gene Accession No. Q9NZN9
Gene Alias A930007I01Rik; AIPL1; AIPL2; aryl hydrocarbon receptor interacting protein like 1; aryl hydrocarbon receptor interacting protein-like 1; aryl hydrocarbon receptor-interacting protein-like 1; aryl-hydrocarbon interacting protein-like 1; aryl-hydrocarbon-interacting protein-like 1; EGK_08083; LCA4
Gene Symbols AIPL1
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human AIPL1. Recombinant protein control fragment (Product #RP-105767).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 23746
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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