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Invitrogen™ AIRE Monoclonal Antibody (609930)
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Catalog No. PIMA524276
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100 μg
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Catalog No. Quantity
PIMA524276 100 μg
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Catalog No. PIMA524276 Supplier Invitrogen™ Supplier No. MA524276
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Description

Rat Monoclonal Antibody

In direct ELISAs, no cross-reactivity with recombinant human AIRE is observed. Reconstitute at 0.5 mg/mL in sterile PBS.

AIRE is a transcriptional regulator protein that binds to DNA as a dimer and tetramer, but not as a monomer, and may be involved in the regulation of gene expression. A nuclear protein, AIRE is a 545 amino acid protein with an HSR domain, two PHD type zinc fingers, and a SAND domain, and may be present in soluble high-molecular-weight complexes. It may form homodimer, homotetramer and also nuclear bodies and interacts with the transcriptional coactivator CBP and CREBBP. Three isoforms of AIRE are reported and one of them is predicted to be a candidate for nuclear-mediated decay (NMD). AIRE is involved in immune regulation and is known to mediate E3 ubiquitin ligase activity. Defects in AIRE are responsible for the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).
TRUSTED_SUSTAINABILITY

Specifications

Antigen AIRE
Applications Flow Cytometry, Western Blot
Classification Monoclonal
Clone 609930
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 5% trehalose and No Preservative
Gene Aire
Gene Accession No. Q9Z0E3
Gene Alias Aire; AIRE protein; AIRE1; APECED; APECED protein; APECED protein homolog; APS1; APSI; Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein; autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog; Autoimmune regulator; autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy); autoimmune regulator AIRE1a; LOW QUALITY PROTEIN: autoimmune regulator; OTTHUMP00000109529; PGA1
Gene Symbols Aire
Host Species Rat
Immunogen E. coli-derived recombinant mouse AIRE Ser476-Ser552 (predicted).
Purification Method Protein A/G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 11634
Target Species Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG2a
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