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Invitrogen™ AIRE Polyclonal Antibody
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Catalog No. PIPA595921
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100 μL
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PIPA595921 100 μL
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Catalog No. PIPA595921 Supplier Invitrogen™ Supplier No. PA595921
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Description

Rabbit Polyclonal Antibody

Positive Samples: MCF7, U-937, HT-29, OVCAR3, SW620, Mouse kidney, Mouse liver; Cellular Location: Cytoplasm, Nucleus Immunogen sequence: HALADHDVVP EDKFQETLHL KEKEGCPQAF HALLSWLLTQ DSTAILDFWR VLFKDYNLER YGRLQPILDS FPKDVDLSQP RKGRKPPAVP KALVPPPRLP T.

AIRE is a transcriptional regulator protein that binds to DNA as a dimer and tetramer, but not as a monomer, and may be involved in the regulation of gene expression. A nuclear protein, AIRE is a 545 amino acid protein with an HSR domain, two PHD type zinc fingers, and a SAND domain, and may be present in soluble high-molecular-weight complexes. It may form homodimer, homotetramer and also nuclear bodies and interacts with the transcriptional coactivator CBP and CREBBP. Three isoforms of AIRE are reported and one of them is predicted to be a candidate for nuclear-mediated decay (NMD). AIRE is involved in immune regulation and is known to mediate E3 ubiquitin ligase activity. Defects in AIRE are responsible for the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).
TRUSTED_SUSTAINABILITY

Specifications

Antigen AIRE
Applications ELISA, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1.57 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Aire
Gene Accession No. O43918, Q9Z0E3
Gene Alias Aire; AIRE protein; AIRE1; APECED; APECED protein; APECED protein homolog; APS1; APSI; Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein; autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog; Autoimmune regulator; autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy); autoimmune regulator AIRE1a; LOW QUALITY PROTEIN: autoimmune regulator; OTTHUMP00000109529; PGA1
Gene Symbols Aire
Host Species Rabbit
Immunogen Synthetic peptide
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 11634, 294328, 326
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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