AIRE Rabbit anti-Human, Mouse, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-173-3878	Proteintech Group Inc 225171AP150UL	150 μL

Description

The autoimmune regulator (AIRE) is a protein that in humans is encoded by the AIRE gene. This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CREB binding protein. The encoded protein plays an important role in immunity by regulating the expression of autoantigens and negative selection of autoreactive T-cells in the thymus. Mutations in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy with candidiasis and ectodermal dystrophy (APECED).

Specifications

• Antigen: AIRE
• Applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human, Mouse
• Gene Accession No.: O43918, Q9Z0E3
• Gene ID (Entrez): 11634, 326
• Immunogen: AIRE Fusion Protein Ag18249
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: AIRE

• Concentration: 0.27 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Alias: AIRE, AIRE1, APECED, APECED protein, APS1, APSI, autoimmune regulator, PGA1
• Gene Symbols: AIRE
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody