Invitrogen™ AKAP12 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA563271

Catalog No. PIPA563271

Description

Immunogen sequence: SKDMSEASEK TMTVEVEGST VNDQQLEEVV LPSEEEGGGA GTKSVPEDDG HALLAERIEK SLVEPKEDEK GDDVDDPENQ NSALADTDAS GGLTKESPDT NGPKQKEKED AQEVELQEGK VHSESDKAIT PQAQEELQKQ ERESAKS Highest antigen sequence identity to the following orthologs: Mouse - 30%, Rat - 34%.

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed in endothelial cells, cultured fibroblasts, and osteosarcoma cells. It associates with protein kinases A and C and phosphatase, and serves as a scaffold protein in signal transduction. This protein and RII PKA colocalize at the cell periphery. This protein is a cell growth-related protein. Antibodies to this protein can be produced by patients with myasthenia gravis. Alternative splicing of this gene results in two transcript variants encoding different isoforms.

Specifications

• Antigen: AKAP12
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: AKAP12
• Gene Alias: A kinase (PRKA) anchor protein (gravin) 12; A kinase (PRKA) anchor protein 12; AI317366; AKAP 250; AKAP12; AKAP-12; AKAP12A; AKAP12B; AKAP12G; AKAP250; A-kinase anchor protein 12; A-kinase anchor protein 250 kDa; A-kinase anchor protein, 250kDa; A-kinase anchoring protein 12; Gag12; gercelin; germ cell lineage protein gercelin; Gravin; kinase scaffold protein gravin; Myasthenia gravis autoantigen; myasthenia gravis autoantigen gravin; Srcs5; Src-Suppressed C Kinase Substrate; SSeCKS; SSeCKS, Gravin, AKAP250; testis specific gene A12; Tsga12; v-src suppressed transcript 5
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 9590
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunocytochemistry
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q02952
• Gene Symbols: AKAP12
• Immunogen: Recombinant protein corresponding to Human AKAP12. Recombinant protein control fragment (Product #RP-103250).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG