Invitrogen™ AKAP13 Polyclonal Antibody

Catalog No.	Quantity
PIPA536342	100 μL

Catalog No. PIPA536342 Supplier Invitrogen™ Supplier No. PA536342

Description

Rabbit Polyclonal Antibody

This antibody detects endogenous protein at a molecular weight of 307 kDa. Purity is >95% by SDS-PAGE.

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms containing c-terminal dbl oncogene homology (DH) and pleckstrin homology (PH) domains. The DH domain is associated with guanine nucleotide exchange activation for the Rho/Rac family of small GTP binding proteins, resulting in the conversion of the inactive GTPase to the active form capable of transducing signals. The PH domain has multiple functions. Therefore, these isoforms function as scaffolding proteins to coordinate a Rho signaling pathway, function as protein kinase A-anchoring proteins and, in addition, enhance ligand-dependent activity of estrogen receptors alpha and beta.

Specifications

• Antigen: AKAP13
• Applications: Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
• Gene: AKAP13
• Gene Accession No.: Q12802
• Gene Alias: 1700026G02Rik; 5730522G15Rik; 5830460E08Rik; A kinase (PRKA) anchor protein 13; AKAP13; AKAP-13; AKAP-Lbc; A-kinase anchor protein 13; A-kinase anchoring protein; A-kinase anchoring protein 13; ARHGEF13; Breast cancer nuclear receptor-binding auxiliary protein; Brx; c-lbc; guanine nucleotide exchange factor Lbc; HA-3; Ht31; Human thyroid-anchoring protein 31; LBC; LBC oncogene; lymphoid blast crisis oncogene; Non-oncogenic Rho GTPase-specific GTP exchange factor; p47; PRKA13; Protein kinase A-anchoring protein 13; PROTO-LB; PROTO-LBC; type II cAMP-dependent protein kinase anchoring protein Ht31
• Gene Symbols: AKAP13
• Host Species: Rabbit
• Immunogen: Synthetic peptide corresponding to amino acids 700-750 of human AKAP 13.
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 11214
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG