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Invitrogen™ AKAP8 Polyclonal Antibody
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Catalog No. PIPA552103
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100 μL
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PIPA552103 100 μL
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Catalog No. PIPA552103 Supplier Invitrogen™ Supplier No. PA552103
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: PEMEGDDNLG GEDKKETPEE VAADVLAEVI TAAVRAVDGE GAPAPESSGE PAEDEGPTDT AEAGSDPQAE QLLEEQVPCG TAHEKGVPKA RSEAAEAGNG AETMAAEAES AQTRVAPAPA AADAEVEQTD AESKDAVP Highest antigen sequence identity to the following orthologs: Mouse - 53%, Rat - 58%.

The type II cAMP-protein kinase (PKA) is a multifunctional kinase with a broad range of substrates. Specificity of PKA signaling is thought to be mediated by the compartmentalization of the kinase to specific sites within the cell. To maintain this specific localization, the R subunit (RII) of PKA interacts with specific RII-anchoring proteins. The family of RII-anchoring proteins has been designated A-kinase anchoring proteins (AKAP). AKAP 95, also known as AKAP 8, is a nuclear matrix protein predominantly expressed in liver, heart, pancreas, kidney and skeletal muscle. During mitosis, AKAP 95 is recruited to the chromosomes and plays an essential role in mitotic progression. Characteristic of its family, AKAP 95 participates in PKA signaling through an interaction with the RII regulatory subunit. In addition, AKAP 95 forms a complex with HA95 and HDAC3 and is required for the deacetylation of Histone H3 in mitosis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen AKAP8
Applications ChIP Assay, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.3 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene AKAP8
Gene Accession No. O43823
Gene Alias 1200016A02Rik; A kinase (PRKA) anchor protein 8; A kinase anchor protein 8; AA673585; AKAP 8; AKAP 95; Akap8; AKAP-8; Akap95; AKAP-95; A-kinase anchor protein 8; A-kinase anchor protein 95 kDa; A-kinase anchor protein, 95kDa; A-kinase anchoring protein 8; AU015639; DKFZp586B1222
Gene Symbols AKAP8
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human AKAP8. Recombinant protein control fragment (Product #RP-102489).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 10270
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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