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Invitrogen™ AKAP8 Polyclonal Antibody
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Catalog No. PIPA5120850
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100 μL
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PIPA5120850 100 μL
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Catalog No. PIPA5120850 Supplier Invitrogen™ Supplier No. PA5120850
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Description

Rabbit Polyclonal Antibody

Positive test controls include: LO2, 293T, BxPC-3, HeLa, Jurkat, mouse thymus. The target is usually found in the following locations: Nucleus matrix. Immunogen sequence: HCLACDMLIP AQPQLLQRHL HSVDHNHNRR LAAEQFKKTS LHVAKSVLNN RHIVKMLEKY LKGEDPFTSE TVDPEMEGDD NLGGEDKKET PEEVAADVLA EVITAAVRAV DGEGAPAPES SGEPAEDEGP TDTAEAGSDP QAEQLLEEQV PCGTAHEKGV PKARSEAAEA GNGAETMAAE AESAQTRVAP APAAADAEVE QTDAESKDAV PTE.

The type II cAMP-protein kinase (PKA) is a multifunctional kinase with a broad range of substrates. Specificity of PKA signaling is thought to be mediated by the compartmentalization of the kinase to specific sites within the cell. To maintain this specific localization, the R subunit (RII) of PKA interacts with specific RII-anchoring proteins. The family of RII-anchoring proteins has been designated A-kinase anchoring proteins (AKAP). AKAP 95, also known as AKAP 8, is a nuclear matrix protein predominantly expressed in liver, heart, pancreas, kidney and skeletal muscle. During mitosis, AKAP 95 is recruited to the chromosomes and plays an essential role in mitotic progression. Characteristic of its family, AKAP 95 participates in PKA signaling through an interaction with the RII regulatory subunit. In addition, AKAP 95 forms a complex with HA95 and HDAC3 and is required for the deacetylation of Histone H3 in mitosis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen AKAP8
Applications ELISA, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1.08 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene AKAP8
Gene Accession No. O43823, Q9DBR0
Gene Alias 1200016A02Rik; A kinase (PRKA) anchor protein 8; A kinase anchor protein 8; AA673585; AKAP 8; AKAP 95; Akap8; AKAP-8; Akap95; AKAP-95; A-kinase anchor protein 8; A-kinase anchor protein 95 kDa; A-kinase anchor protein, 95kDa; A-kinase anchoring protein 8; AU015639; DKFZp586B1222
Gene Symbols AKAP8
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 480-692 of human AKAP8 (NP_005849.1).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 10270, 56399
Target Species Human, Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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