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Invitrogen™ AKAP8L Polyclonal Antibody
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Catalog No. PIPA559993
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100 μL
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PIPA559993 100 μL
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Catalog No. PIPA559993 Supplier Invitrogen™ Supplier No. PA559993
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: DEEGKEDGRE EGKEDPEKGA LTTQDENGQT KRKLQAGKKS QDKQKKRQRD RMVERIQFVC SLCKYRTFYE DEMASHLDSK FHKEHFKYVG TKLPKQTAD Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 93%.

Could play a role in constitutive transport element (CTE)-mediated gene expression by association with DHX9. Increases CTE-dependent nuclear unspliced mRNA export (PubMed:10748171, PubMed:11402034). Proposed to target PRKACA to the nucleus but does not seem to be implicated in the binding of regulatory subunit II of PKA (PubMed:10761695, PubMed:11884601). May be involved in nuclear envelope breakdown and chromatin condensation. May be involved in anchoring nuclear membranes to chromatin in interphase and in releasing membranes from chromating at mitosis (PubMed:11034899). May regulate the initiation phase of DNA replication when associated with TMPO isoform Beta (PubMed:12538639). Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3; in this function seems to act redundantly with AKAP8 (PubMed:16980585). May be involved in regulation of pre-mRNA splicing (PubMed:17594903). [UniProt].
TRUSTED_SUSTAINABILITY

Specifications

Antigen AKAP8L
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene AKAP8L
Gene Accession No. Q9ULX6
Gene Alias A kinase (PRKA) anchor protein 8-like; AKAP8L; AKAP8-like protein; A-kinase anchor protein 8-like; A-kinase anchoring protein 8 like; HA95; HAP95; Helicase A-binding protein 95; helicase A-binding protein 95 kDa; homologous to AKAP95 protein; HRIHFB2018; LOC539700 protein; NAKAP; NAKAP95; neighbor of AKAP; Neighbor of AKAP95; neighbor of A-kinase anchoring protein 95; neighbor of A-kinase-anchoring protein 95; testis tissue sperm-binding protein Li 90mP
Gene Symbols AKAP8L
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human AKAP8L. Recombinant protein control fragment (Product #RP-98865).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 26993
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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