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AKAP95/AKAP8 Rabbit anti-Human, Polyclonal, Bioss Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  BiossSupplier Diversity Partner BS1473R

Catalog No. 50-198-3329


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Description

Description

The type II cAMP-protein kinase (PKA) is a multifunctional kinase with a broad range of substrates. Specificity of PKA signaling is thought to be mediated by the compartmentalization of the kinase to specific sites within the cell. To maintain this specific localization, the R subunit (RII) of PKA interacts with specific RII-anchoring proteins. The family of RII-anchoring proteins has been designated A-kinase anchoring proteins (AKAP). AKAP 95, also known as AKAP 8, is a nuclear matrix protein predominantly expressed in liver, heart, pancreas, kidney and skeletal muscle. During mitosis, AKAP 95 is recruited to the chromosomes and plays an essential role in mitotic progression. Characteristic of its family, AKAP 95 participates in PKA signaling through an interaction with the RII regulatory subunit. In addition, AKAP 95 forms a complex with HA95 and HDAC3 and is required for the deacetylation of Histone H3 in mitosis.
Specifications

Specifications

AKAP95/AKAP8
Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Unconjugated
AKAP8
Liquid
Rabbit
IgG
100 μL
-20°C
Primary
10270
AKAP8
1 μg/mL
PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
O43823
1200016A02Rik; A kinase (PRKA) anchor protein 8; A kinase anchor protein 8; AA673585; AKAP 8; AKAP 95; AKAP8; AKAP-8; Akap95; AKAP-95; A-kinase anchor protein 8; A-kinase anchor protein 95 kDa; A-kinase anchor protein, 95kDa; A-kinase anchoring protein 8; AU015639; DKFZp586B1222
KLH conjugated synthetic peptide derived from human AKAP95.
Protein A
RUO
Antibody
Polyclonal
Human
SDS
Documents
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