AKIRIN2 Rabbit anti-Human, Polyclonal, Bioss

Catalog No.	Quantity
50-198-8805	100 μL

Catalog No. 50-198-8805 Supplier Bioss Supplier No. BS9082R

Description

Rabbit Polyclonal Antibody

The highly conserved, nuclear-localized Akirin1 and Akirin2 proteins critically regulate the transcription of NF-kappa-B-dependent genes and are required for defense against Gram-negative bacteria in the immune deficiency and NF-kappa-B pathways. Akirin1 is dispensable in the mouse, and neither knockout mice nor cells derived from them have obvious distinctive phenotypes. In contrast, Akirin2 is required for development in the mouse and knockout of both Akirin homologs in mice show that Akirin2 is required downstream of toll-like receptor (TLR), TNF-a and IL-1-b signaling, and for the production of IL-6. Akirin2 is functionally closer to the single gene in Drosophila, as the homozygous null D. melanogaster Akirin mutants show a similar, mid-to-early embryonic death.

Specifications

• Antigen: AKIRIN2
• Applications: Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 1 μg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
• Gene: AKIRIN2
• Gene Accession No.: Q53H80
• Gene Alias: 14-3-3 beta; 2700059D21Rik; AA114675; AA522011; akirin 2; AKIRIN2; Akirin-2; akirin2 {ECO:0000250; AU019887; C6orf166; dJ486L4.2; EMBL:BAE81786.1}; FBI1; Fourteen-three-three beta interactant 1; fourteen-three-three beta interactant 1 {ECO:0000312; Fourteen-three-three beta interacting-protein 1; RGD1307791; UniProtKB:Q53H80}
• Gene Symbols: AKIRIN2
• Host Species: Rabbit
• Immunogen: KLH conjugated synthetic peptide derived from human AKIRIN2.
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 55122
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG