AKIRIN2 Rabbit anti-Human, Polyclonal, Bioss

Rabbit Polyclonal Antibody

Supplier:  Bioss BS9082R

Catalog No. 50-198-8805

Description

The highly conserved, nuclear-localized Akirin1 and Akirin2 proteins critically regulate the transcription of NF-kappa-B-dependent genes and are required for defense against Gram-negative bacteria in the immune deficiency and NF-kappa-B pathways. Akirin1 is dispensable in the mouse, and neither knockout mice nor cells derived from them have obvious distinctive phenotypes. In contrast, Akirin2 is required for development in the mouse and knockout of both Akirin homologs in mice show that Akirin2 is required downstream of toll-like receptor (TLR), TNF-a and IL-1-b signaling, and for the production of IL-6. Akirin2 is functionally closer to the single gene in Drosophila, as the homozygous null D. melanogaster Akirin mutants show a similar, mid-to-early embryonic death.

Specifications

• Antigen: AKIRIN2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: AKIRIN2
• Gene Alias: 14-3-3 beta; 2700059D21Rik; AA114675; AA522011; akirin 2; AKIRIN2; Akirin-2; akirin2 {ECO:0000250; AU019887; C6orf166; dJ486L4.2; EMBL:BAE81786.1}; FBI1; Fourteen-three-three beta interactant 1; fourteen-three-three beta interactant 1 {ECO:0000312; Fourteen-three-three beta interacting-protein 1; RGD1307791; UniProtKB:Q53H80}
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 55122
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 μg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
• Gene Accession No.: Q53H80
• Gene Symbols: AKIRIN2
• Immunogen: KLH conjugated synthetic peptide derived from human AKIRIN2.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG