MilliporeSigma Akt/PKB, PH Domain, Mouse, Alexa Fluor 647, Clone: SKB1,
Mouse Monoclonal Antibody
Manufacturer: MilliporeSigma 05591AF647
DescriptionRAC-alpha serine/threonine-protein kinase (EC 220.127.116.11; UniProt P31749; also known as PKB, PKB alpha, Protein kinase B, Protein kinase B alpha, Proto-oncogene c-Akt, RAC-PK-alpha) is encoded by the AKT1 (also known as PKB, RAC) gene (Gene ID 207) in human. AKTs (protein kinase Bs) are serine/threonine kinases that play an important role in signal transduction pathways involved in cell proliferation, apoptosis, angiogenesis, and diabetes. There exit three types of AKTs (α, β, γ or AKT 1, 2, 3) sharing a high degree of homology, but differing slightly in the localization of their regulatory phosphorylation sites. AKT α is the predominant isoform in most tissues, whereas the highest expression of AKT β is observed in the insulin-responsive tissues, and AKT γ is abundant in brain tissue. Each AKT type is composed of three functionally distinct regions, including an N-terminal pleckstrin homology (PH) domain that provides a lipid-binding module to direct Akt to PIP2 and PIP3, a central catalytic domain, and a C-terminal hydrophobic motif.
|Akt/PKB, PH Domain|
|Alexa Fluor 647|
|AKT1, PKB, RAC|
|GST-fusion protein corresponding to residues 1-149 of human Akt1.|
|Protein G Purified|
|Stable for 1 year at 2°-8°C from date of receipt.|
|Clone SKB1 recognizes Akt1 and Akt2, but not Akt3, GST fusion proteins at 100 ng by immunoblotting analysis using the unconjugated antibody (Mfr. No. 05-591).|
|Please refer to lot specific datasheet.|
|Purified mouse monoclonal IgG antibody conjugate in PBS with 15 mg/mL BSA and 0.1 % Sodium Azide.|
|Apoptosis & Cancer|
|Human, Mouse, Rat|
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For Research Use Only. Not for use in diagnostic procedures.