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AKT1 Rabbit anti-Human, Clone:RM316, Abnova™

Catalog No. 89333297 Shop All Abnova Corporation Products
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89-333-297 100 μL
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Catalog No. 89-333-297 Supplier Abnova Corporation Supplier No. MAB16941
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Description

Rabbit monoclonal antibody raised against huamn AKT1.

The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq]

Specifications

Antigen AKT1
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone RM316
Conjugate Unconjugated
Description v-akt murine thymoma viral oncogene homolog 1
Dilution Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:200-500)
Western Blot (1:5000-10000)
The optimal working dilution should be determined by the end user.
Formulation In PBS (50% glycerol, 1% BSA, 0.09% sodium azide)
Gene AKT1
Gene Alias AKT, MGC99656, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA
Host Species Rabbit
Immunogen A peptide corresponding to PH domain of human AKT1.
Quantity 100 μL
Gene ID (Entrez) 207
Test Specificity This antibody reacts to human AKT (PH domain). It may also react to mouse or rat AKT, as predicted by immunogen homology.
Target Species Human
Content And Storage Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
Product Type Antibody
Form Liquid
Isotype IgG
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