Invitrogen™ alanyl-tRNA Synthetase Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA529516

Catalog No. PIPA529516

Description

Recommended positive controls: A431, H1299, HeLa, HepG2, mouse liver. Predicted reactivity: Mouse (95%), Rat (92%), Xenopus laevis (84%), Chicken (86%), Bovine (92%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The human alanyl-tRNA synthetase (AARS) belongs to a family of tRNA synthases, of the class II enzymes. Class II tRNA synthases evolved early in evolution and are highly conserved. This is reflected by the fact that 498 of the 968-residue polypeptide human AARS shares 41% identity witht the E. coli protein. tRNA synthases are the enzymes that interpret the RNA code and attach specific aminoacids to the tRNAs that contain the cognate trinucleotide anticodons. They consist of a catalytic domain which interacts with the amino acid acceptor-T psi C helix of the tRNA, and a second domain which interacts with the rest of the tRNA structure.

Specifications

• Antigen: alanyl-tRNA Synthetase
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: AARS1
• Gene Alias: Aars; AI316495; alanine tRNA ligase 1, cytoplasmic; alanine--tRNA ligase, cytoplasmic; alanine--tRNA ligase, cytoplasmic {ECO:0000255; Alanyl-tRNA synthetase; alanyl-tRNA synthetase {ECO:0000255; alanyl-tRNA synthetase, cytoplasmic; alaRS; alaRS {ECO:0000255; C76919; CMT2N; EIEE29; HAMAP-Rule:MF_03133}; Protein sticky; Renal carcinoma antigen NY-REN-42; sti
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 16, 234734
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.23 mg/mL
• Formulation: 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: P49588, Q8BGQ7
• Gene Symbols: AARS1
• Immunogen: Recombinant fragment corresponding to a region within amino acids 461 and 723 of Human alanyl-tRNA synthetase.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov