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Invitrogen™ ALAS1 Recombinant Rabbit Monoclonal Antibody (2A9)
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Catalog No. PIMA538338
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PIMA538338 100 μL
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Catalog No. PIMA538338 Supplier Invitrogen™ Supplier No. MA538338
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Description

Rabbit Recombinant Monoclonal Antibody

This antibody has been tested in direct-ELISA.

ALAS-1 is a nuclear-encoded mitochondrial matrix enzyme which catalyzes the condensation of glycine with succinyl-CoA to form delta-amino levulinate, CO2 and CoA. It regulates the first and rate-limiting step of heme biosynthetic pathway. It is one of the two isoforms of ALAS and is a pyridoxal-5' phosphate dependant housekeeping enzyme. It is ubiquitously expressed and is responsible of providing heme for cytochromes and other hemoproteins. ALAS1 in liver undergoes negative feedback regulation by heme. Transcription of ALAS1 gene is stimulated by cAMP and respiratory uncoupling whereas Phorbol esters and insulin repress ALAS1 gene expression. ALAS1 is suggested to be involved in reciprocal regulation of Heme biosynthesis and circadian clock suggesting a potential target for treatment of circadian disorders. ALAS1 gene expression is down regulated in Acute Liver failure resulting in altered heme metabolism and liver function.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ALAS1
Applications Western Blot
Classification Recombinant Monoclonal
Clone 2A9
Concentration 0.58 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol, 150mM NaCl and 0.02% sodium azide; pH 7.4
Gene ALAS1
Gene Accession No. P13196
Gene Alias 5'-aminolevulinate synthase 1; 5-aminolevulinate synthase 1; 5-aminolevulinate synthase, nonspecific, mitochondrial; 5-aminolevulinic acid synthase 1; ALAS; ALA-S; ALAS1; Alas-1; ALAS3; ALASH; Alas-h; ALAS-N; aminolevulinate synthase H; aminolevulinate, delta-, synthase 1; aminolevulinic acid synthase 1; delta-ALA synthase 1; delta-ALA synthetase; delta-aminolevulinate synthase 1; MIG4; migration-inducing protein 4; OK/SW-cl.121; succinyl-CoA: glycine C-succinyl transferase
Gene Symbols ALAS1
Host Species Rabbit
Immunogen A synthesized peptide derived from human Alas1.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 211
Target Species Human
Content And Storage -20°C or -80°C if preferred
Product Type Antibody
Form Liquid
Isotype IgG
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