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Invitrogen™ ALDH1L1 Monoclonal Antibody (7G8), Biotin, eBioscience™
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Catalog No. 13959582
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100 μg
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13-959-582 100 μg
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Catalog No. 13-959-582 Supplier Invitrogen™ Supplier No. 13959582
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Description

Mouse Monoclonal Antibody

This 7G8 monoclonal antibody reacts with human 10-formyltetrahydrofolate dehydrogenase (ALDH1L1) a protein involved in folate metabolism. The cytosolic enzyme, with homology to the aldehyde dehydrogenase (ALDH) family, is involved in the conversion of 10-formyltetrahydrofolate, NADP and water to tetrahydrofolate, NADPH and carbon dioxide. Folate metabolism is essential for cell growth and proliferation and decreased levels of folate have been implicated in neural tube defects in addition to increased cancer risk. This isoform (1L1) is expressed in glial cells has been identified as a highly specific marker for astrocytes labeling both the cell body and processes. Applications Reported: This 7G8 antibody has been reported for use in flow cytometric analysis, western blotting, immunohistochemical staining, and immunocytochemistry. Applications Tested: This 7G8 antibody has been tested by immunohistochemistry on formalin-fixed paraffin embedded human tissue with low pH antigen retrieval at less than or equal to 20 μg/mL. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Filtration: 0.2 μm post-manufacturing filtered.

ALDH1L1 catalyzes the conversion of 10-formyltetrahydrofolate, NADP, and water to tetrahydrofolate, NADPH, and carbon dioxide. The encoded protein belongs to the aldehyde dehydrogenase family and is responsible for formate oxidation in vivo. Deficiencies in this gene can result in an accumulation of formate and subsequent methanol poisoning.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ALDH1L1
Applications Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Monoclonal
Clone 7G8
Concentration 0.5 mg/mL
Conjugate Biotin
Formulation PBS with 0.09% sodium azide; pH 7.2
Gene ALDH1L1
Gene Accession No. O75891
Gene Alias 10-formyltetrahydrofolate dehydrogenase; 10fTHF; 10-fTHF; 10FTHFDH; 10-FTHFDH; 1810048F20Rik; aldehyde dehydrogenase 1 family member L1; aldehyde dehydrogenase 1 family, member L1; aldehyde dehydrogenase family 1 member L1; Aldh1l1; Cytosolic 10-formyltetrahydrofolate dehydrogenase; DKFZp781N0997; FBP-CI; FDH; formyltetrahydrofolate dehydrogenase; Fthfd; LOC100855730; MER57B-ALDH1L1; Neut2
Gene Symbols ALDH1L1
Host Species Mouse
Purification Method Affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 10840
Target Species Human
Content And Storage 4°C, store in dark, DO NOT FREEZE!
Product Type Antibody
Form Liquid
Isotype IgG2b κ
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