Invitrogen™ ALDH2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA527414

Catalog No. PIPA527414

Description

Recommended positive controls: GL261, C8D30, BCL-1, Raw264.7, HepG2, HepG2 cytoplasm extract. Predicted reactivity: Mouse (95%), Rat (96%), Xenopus laevis (82%), Pig (94%), Bovine (94%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

ALDH2 belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of this enzyme, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Asians have only the cytosolic isozyme, missing the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Asians than among Caucasians could be related to the absence of the mitochondrial isozyme.

Specifications

• Antigen: ALDH2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Aldh2
• Gene Alias: acetaldehyde dehydrogenase 2; Ahd1; Ahd-1; Ahd5; Ahd-5; AHD-M1; aldehyde dehydrogenase 2 family (mitochondrial); aldehyde dehydrogenase 2, mitochondrial; aldehyde dehydrogenase, mitochondrial; ALDH class 2; ALDH1; ALDH2; ALDH-E2; ALDHI; ALDM; EC 1.2.1.3; liver mitochondrial ALDH; MGC1806; mitochondrial aldehyde dehydrogenase; nucleus-encoded mitochondrial aldehyde dehydrogenase 2
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 11669, 217, 29539
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot, Western Blot
• Concentration: 0.23 mg/mL
• Formulation: PBS with 1% BSA, 20% glycerol and 0.025% ProClin 300; pH 7
• Gene Accession No.: P05091, P11884, P47738
• Gene Symbols: Aldh2
• Immunogen: Recombinant fragment corresponding to a region within amino acids 151 and 517 of Human ALDH2.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov