Invitrogen™ ALDH3A1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA585334

Catalog No. PIPA585334

Description

Keep as concentrated solution. Predicted reactivity: Mouse (82%), Rat (83%), Dog (91%), Bovine (89%). Positive Control: mouse eye, Whole Cornea. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Aldh3A1 is a member of the aldehyde dehydrogenase superfamily, a group of NAD(P)(+)-dependent enzymes that catalyze the oxidation of a wide spectrum of aliphatic and aromatic aldehydes. Aldh3A1 is highly expressed in stomach and even more strongly in cornea, representing between 5 to 50% of the water soluble protein fraction in mammalian corneas. It is thought that Aldh3A1 acts to protect the cornea from UV-induced oxidative stress by not only detoxification of reactive aldehydes by also through the direct absorption of UV energy. However, corneas from Aldh3A1-null mice are indistinguishable from those from wild-type mice; mice lacking both Aldh3A1 and Aldh1A1 showed increased cataract formation following UVB exposure, suggesting that Aldh1A1 may be able to compensate for the loss of Aldh3A1.

Specifications

• Antigen: ALDH3A1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ALDH3A1
• Gene Alias: Ahd4; Ahd-4; AHDC; Ahd-c; alcohol dehydrogenase family 3, subfamily A1; Aldd; Aldehyde dehydrogenase (Ahd-c); Aldehyde dehydrogenase 3; aldehyde dehydrogenase 3 family member A1; aldehyde dehydrogenase 3 family, member A1; aldehyde dehydrogenase 3 family, memberA1; aldehyde dehydrogenase 3, stomach cytosolic (class 3); aldehyde dehydrogenase 3A1; aldehyde dehydrogenase 4; aldehyde dehydrogenase class 3; aldehyde dehydrogenase family 3 member A1; aldehyde dehydrogenase family 3 subfamily A1; aldehyde dehydrogenase family 3, member A1; aldehyde dehydrogenase family 3, subfamily A1; aldehyde dehydrogenase isozyme 3; aldehyde dehydrogenase type III; aldehyde dehydrogenase, dimeric NADP-preferring; Aldh; Aldh3; Aldh3a1; Aldh4; ALDHIII; BCP54; bovine corneal protein 54; corneal 15.8 kDa protein; corneal epithelium; corneal protein 54, transparentin; dehydrogenase 3, dimeric NAPD-prefering; dioxin-inducible aldehyde dehydrogenase 3; HTC-ALDH; MGC10406; stomach aldehyde dehydrogenase; transparentin; Tumor-associated aldehyde dehydrogenase; tumor-associated aldehyde dehydrogenase tumor ALDH
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 11670, 218, 281617
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Frozen), Western Blot
• Concentration: 0.61 mg/mL
• Formulation: 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: P30838, P30907, P47739
• Gene Symbols: ALDH3A1
• Immunogen: Recombinant protein encompassing a sequence within the center region of human aldehyde dehydrogenase 3A1.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Bovine
• Product Type: Antibody
• Isotype: IgG