ALDH3A2 Monoclonal Antibody (OTI1H10), TrueMAB™, OriGene

Mouse Monoclonal Antibody

Supplier:  OriGene TA503143

Catalog No. 50-167-4109

Description

Aldh3A2 is a member of the aldehyde dehydrogenase superfamily, a group of NAD(P)(+)-dependent enzymes that catalyze the oxidation of a wide spectrum of aliphatic and aromatic aldehydes. Aldehyde dehydrogenase enzymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. Aldh3A2 catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Mutations in the Aldh3A2 gene cause Sjogren-Larrson syndrome, an inherited neurocutaneous disorder. Patients with this disorder display ichthyosis, mental retardation and spastic diplegia. The pathogenesis of the cutaneous and neurological symptoms is thought to result from abnormal lipid accumulation in the membranes of skin and brain, the formation of aldehyde Schiff base adducts with amine-containing lipids or proteins, or defective eicosanoid metabolism.

Specifications

• Antigen: ALDH3A2
• Classification: Monoclonal
• Concentration: 0.52 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: P51648
• Gene Symbols: ALDH3A2
• Immunogen: Full length human recombit protein of human ALDH3A2 produced in HEK293T cell.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2b

• Applications: Western Blot
• Clone: OTI1H10
• Conjugate: Unconjugated
• Gene: ALDH3A2
• Gene Alias: ALDH10, FALDH, SLS
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 224
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid