Invitrogen™ ALDH5A1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA520609

Catalog No. PIPA520609

Description

A suggested positive control is mouse liver tissue lysate. PA5-20609 can be used with blocking peptide PEP-0729.

Aldh5A1 is a member of the aldehyde dehydrogenase superfamily, a group of NAD(P)(+)-dependent enzymes that catalyze the oxidation of a wide spectrum of aliphatic and aromatic aldehydes. Aldehyde dehydrogenase enzymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. Aldh5A1 is a mitochondrial NAD(+)-dependent succinic semialdehyde dehydrogenase. A deficiency of this enzyme, known as 4-hydroxybutyricaciduria, results in a disorder of the neurotransmitter 4-aminobutyric acid (GABA). Symptoms usually include static encephalopathy, associated with developmental delays, hypotonia, ataxia, speech defects, and seizures. At least two isoforms of Aldh5A1 are known to exist.

Specifications

• Antigen: ALDH5A1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ALDH5A1
• Gene Alias: 6330403E24Rik; Ahd1; Ahd-1; aldehyde dehydrogenase 1, mitochondrial; aldehyde dehydrogenase 5 family member A1; aldehyde dehydrogenase 5 family, member A1; aldehyde dehydrogenase 5 family, member A1 (succinate-semialdehyde dehydrogenase); aldehyde dehydrogenase family 5 member A1; aldehyde dehydrogenase family 5, subfamily A1; ALDH5A1; aldhehyde dehydrogenase family 5, subfamily A1; D630032B01Rik; mitochondrial succinate semialdehyde dehydrogenase; NAD(+)-dependent succinic semialdehyde dehydrogenase; OTTMUSG00000000613; SSADH; SSDH; Ssdh1; Succinate-semialdehyde dehydrogenase, mitochondrial; succinic semialdehyde dehydrogenase
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 214579, 291133, 7915
• Content And Storage: Maintain refrigerated at 2°C to 8°C for up to 3 months. For long term storage store at -20°C
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: P51649, P51650, Q8BWF0
• Gene Symbols: ALDH5A1
• Immunogen: a 22 amino acid peptide near the carboxy terminus of the human Aldh5A1.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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