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Invitrogen™ Aldolase B Polyclonal Antibody
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Catalog No. PIPA530218
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100 μL
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PIPA530218 100 μL
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Catalog No. PIPA530218 Supplier Invitrogen™ Supplier No. PA530218
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: 293T, A431, Jurkat, Raji, mouse liver, PC-12, Rat2, mouse brain, rat brain. Predicted reactivity: Human (99%), Mouse (96%), Rat (96%), Zebrafish (82%), Rabbit (98%), Chicken (84%), Sheep (93%), Bovine (94%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Fructose-1,6-bisphosphate aldolase is a tetrameric glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Vertebrates have 3 aldolase isozymes which are distinguished by their electrophoretic and catalytic properties. Differences indicate that aldolases A, B, and C are distinct proteins, the products of a family of related 'housekeeping' genes exhibiting developmentally regulated expression of the different isozymes. The developing embryo produces aldolase A, which is produced in even greater amounts in adult muscle where it can be as much as 5% of total cellular protein. In adult liver, kidney and intestine, aldolase A expression is repressed and aldolase B is produced. In brain and other nervous tissue, aldolase A and C are expressed about equally. There is a high degree of homology between aldolase A and C. Defects in ALDOB cause hereditary fructose intolerance.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Aldolase B
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.06 mg/mL
Conjugate Unconjugated
Formulation PBS with 20% glycerol and 0.025% ProClin 300; pH 7
Gene Aldob
Gene Accession No. P00884, P05062, Q91Y97
Gene Alias ALDB; Aldo2; Aldo-2; ALDOB; Aldolase 2; aldolase 2, B isoform; Aldolase B fructose-biphosphate; Aldolase B, fructose-biphosphate; aldolase B, fructose-bisphosphatase; aldolase B, fructose-bisphosphate; aldolase, fructose-bisphosphate B; BC016435; Fructose-bisphosphate aldolase B; LIV10; Liver-type aldolase
Gene Symbols Aldob
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human Aldolase B. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 229, 230163, 24190
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

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