Invitrogen™ Alivin 1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA14357

Catalog No. PA14357

Description

PA1-4357 detects the alivin 1 protein in mouse and rat samples. PA1-4357 has been successfully used in Western blot procedures. By Western blot this antibody detects bands of ~63 and 66 kDa representing alivin 1 in mouse brain lysate. The PA1-4357 immunogen is a synthetic peptide correspondiing to residues T(449) G D A S A D D R K A G K R V V(464) of mouse and rat alivin 1. There is 81% sequence identity to human.

A novel primary response gene, Alivin 1 (ali1), is an activity-dependent gene and promotes survival of neurons. Sequence analyses reveal that rat, mouse, and human Ali1 proteins contain seven leucine-rich repeats, one IgC2-like loop and a transmembrane domain, and display homology to Kek and Trk families. Results suggest that expression of ali1 promotes depolarization-dependent survival of the granule neuron. Mouse ali1 was mapped to a locus approximately 55.3 cM from the centromere on chromosome 15 that is syntenic to positional candidate loci for familial Alzheimer's disease type 5 and Parkinson's disease 8 on human chromosome 12.

Specifications

• Antigen: Alivin 1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Amigo2
• Gene Alias: adhesion molecule with Ig like domain 2; adhesion molecule with Ig-like domain 2; AI415330; Ali1; alivin 1; alivin-1; amigo2; AMIGO-2; amigo2 {ECO:0000312; amphoterin induced gene 2; amphoterin induced gene and ORF 2; amphoterin-induced protein 2; AW208913; DEGA; differentially expressed in gastric adenocarcinoma; differentially expressed in gastric adenocarcinomas; EMBL:AAO48951.1}; transmembrane protein AMIGO2
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 105827, 300186
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: Q7TNJ4, Q80ZD9
• Gene Symbols: Amigo2
• Immunogen: Synthetic peptide corresponding to residues T(449) G D A S A D D R K A G K R V V(464) of mouse and rat alivin 1.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Mouse, Rat
• Product Type: Antibody
• Isotype: IgG