ALK Mouse anti-Human, Clone: OTI1E12, lyophilized, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene CF800730

Catalog No. 50-166-5288

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

The 2;5 chromosomal translocation is frequently associated with anaplastic large cell lymphomas. The translocation creates a fusion gene consisting of the ALK gene and the nucleophosmin gene: the 3′ half of ALK, derived from chromosome 2, is fused to the 5′ portion of NPM from chromosome 5. A recent study shows that the product of the NPM-ALK fusion gene is oncogenic. The deduced amino acid sequences reveal that ALK is a novel receptor protein-tyrosine kinase having a putative transmembrane domain and an extracellular domain. These sequences are absent in the product of the transforming NPM-ALK gene. ALK shows the greatest sequence similarity to LTK. ALK plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system.

Specifications

• Antigen: ALK
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: ALK
• Gene Alias: CD246, NBLST3
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 238
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: OTI1E12
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: Q9UM73
• Gene Symbols: ALK
• Immunogen: Full length human recombit protein of human ALK produced in HEK293T cell
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1