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ALK Rat anti-Human, Clone: OTI13A1, lyophilized, TrueMAB™
SDP

Rat Monoclonal Antibody

Supplier:  OriGene CF801097

Encompass_Preferred

Catalog No. 50-166-5450


May include imposed supplier surcharges.
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Description

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

The 2;5 chromosomal translocation is frequently associated with anaplastic large cell lymphomas. The translocation creates a fusion gene consisting of the ALK gene and the nucleophosmin gene: the 3′ half of ALK, derived from chromosome 2, is fused to the 5′ portion of NPM from chromosome 5. A recent study shows that the product of the NPM-ALK fusion gene is oncogenic. The deduced amino acid sequences reveal that ALK is a novel receptor protein-tyrosine kinase having a putative transmembrane domain and an extracellular domain. These sequences are absent in the product of the transforming NPM-ALK gene. ALK shows the greatest sequence similarity to LTK. ALK plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system.
Specifications

Specifications

ALK
Monoclonal
Unconjugated
ALK
CD246, NBLST3
Rat
Affinity Chromatography
RUO
238
-20° C, Avoid Freeze/Thaw Cycles
Lyophilized
Western Blot
OTI13A1
PBS with 8% trehalose and no preservative; pH 7.3
Q9UM73
ALK
Human recombit protein fragment corresponding to amino acids 1060-1620 of human ALK produced in SF9 cell.
100 μg
Primary
Human
Antibody
IgG2a
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