Invitrogen™ ALK Recombinant Rabbit Monoclonal Antibody (RM361)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA533093

Catalog No. PIMA533093

Description

Specificity: reacts to human total ALK protein including ALK fusion proteins. Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Anaplastic Lymphoma Receptor Tyrosine Kinase (ALK) belongs to the insulin receptor superfamily. It is vital for brain development. Mutations, rearrangements, and amplifications in the ALK gene have been found in tumors, including anaplastic large cell lymphoma, neurblastoma, and non-small cell lung cancer. Chromosomal rearrangement is the most common genetic alteration. The translocation creates a fusion gene consisting of the ALK gene and the nucleophosmin gene: the 3' half of ALK, derived from chromosome 2, is fused to the 5' portion of NPM from chromosome 5. A recent study shows that the product of the NPM-ALK fusion gene is oncogenic. The deduced amino acid sequences reveal that ALK is a novel receptor protein-tyrosine kinase having a putative transmembrane domain and an extracellular domain. These sequences are absent in the product of the transforming NPM-ALK gene. ALK shows the greatest sequence similarity to LTK. ALK plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system.

Specifications

• Antigen: ALK
• Classification: Recombinant Monoclonal
• Concentration: 0.1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide
• Gene Accession No.: Q9UM73
• Gene Symbols: ALK
• Immunogen: A peptide corresponding to the C-terminus of human ALK (Anaplastic lymphoma kinase).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

• Applications: Western Blot, Immunohistochemistry (Paraffin), Western Blot
• Clone: RM361
• Conjugate: Unconjugated
• Gene: ALK
• Gene Alias: Alk; ALK tyrosine kinase receptor; ALK/NPM1 fusion gene; anaplastic lymphoma kinase; Anaplastic lymphoma kinase Ki1; Anaplastic Lymphoma Kinase p80; anaplastic lymphoma receptor tyrosine kinase; CD246; CD246 antigen; EC 2.7.10.1; kinase ALK; mutant anaplastic lymphoma kinase; NBLST3; npm-alk; p80; Tcrz; TFG/ALK
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 238
• Content And Storage: -20°C
• Form: Liquid