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Invitrogen™ ALK Recombinant Rabbit Monoclonal Antibody (RM361)
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Catalog No. PIMA533093
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100 μL
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PIMA533093 100 μL
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Catalog No. PIMA533093 Supplier Invitrogen™ Supplier No. MA533093
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Description

Rabbit Recombinant Monoclonal Antibody

Specificity: reacts to human total ALK protein including ALK fusion proteins. Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Anaplastic Lymphoma Receptor Tyrosine Kinase (ALK) belongs to the insulin receptor superfamily. It is vital for brain development. Mutations, rearrangements, and amplifications in the ALK gene have been found in tumors, including anaplastic large cell lymphoma, neurblastoma, and non-small cell lung cancer. Chromosomal rearrangement is the most common genetic alteration. The translocation creates a fusion gene consisting of the ALK gene and the nucleophosmin gene: the 3' half of ALK, derived from chromosome 2, is fused to the 5' portion of NPM from chromosome 5. A recent study shows that the product of the NPM-ALK fusion gene is oncogenic. The deduced amino acid sequences reveal that ALK is a novel receptor protein-tyrosine kinase having a putative transmembrane domain and an extracellular domain. These sequences are absent in the product of the transforming NPM-ALK gene. ALK shows the greatest sequence similarity to LTK. ALK plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ALK
Applications Western Blot, Immunohistochemistry (Paraffin), Western Blot
Classification Recombinant Monoclonal
Clone RM361
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide
Gene ALK
Gene Accession No. Q9UM73
Gene Alias Alk; ALK tyrosine kinase receptor; ALK/NPM1 fusion gene; anaplastic lymphoma kinase; Anaplastic lymphoma kinase Ki1; Anaplastic Lymphoma Kinase p80; anaplastic lymphoma receptor tyrosine kinase; CD246; CD246 antigen; EC 2.7.10.1; kinase ALK; mutant anaplastic lymphoma kinase; NBLST3; npm-alk; p80; Tcrz; TFG/ALK
Gene Symbols ALK
Host Species Rabbit
Immunogen A peptide corresponding to the C-terminus of human ALK (Anaplastic lymphoma kinase).
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 238
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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