Invitrogen™ Human ALK [T1151, L1152insT], GST Tag Recombinant Protein

Description

Recombinant Protein

ALK receptor tyrosine kinase or anaplastic lymphoma kinase was originally identified as a member of the insulin receptor subfamily that acquires transforming capability when truncated and fused to NPM (nucleophosmin) in the t(2;5) chromosomal rearrangement associated with ALCL. Many chromosomal rearrangements leading to enhanced ALK activity have been described and are implicated in a number of cancer types. In the nervous system, ALK in the presence of ligand appears essential for axonal guidance, whereas in the absence of ligand, ALK expression can lead to developmental neuronal apoptosis.

Specifications

• Accession Number: Q9UM73
• Concentration: See Label
• For Use With (Application): Kinase Assay
• Formulation: 50 mM tris HCl with 0.1 mM EDTA, 0.1 mM PMSF, 0.25 mM DTT, 10 mM glutathione, 150 mM NaCl, 25% glycerol and no preservative; pH 7.5
• Gene ID (Entrez): 238
• Molecular Weight (g/mol): 88.9 kDa
• Name: Human ALK [T1151, L1152insT], GST Tag
• Quantity: 100 μg
• Gene Alias: ALK
• Common Name: ALK (T1151, L1152insT Mutant)
• KinaseFamily: Insulin & IGF Receptors
• Protein Length: 1060-end
• Conjugate: Unconjugated
• Species: Human
• Recombinant: Recombinant
• Protein Tag: GST-tag
• Content And Storage: -80°C, Avoid Freeze/Thaw Cycles
• Shipping Condition: Dry Ice
• Expression System: Insect cells
• Protein Form: Recombinant, Active, Catalytic
• Form: Liquid