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Invitrogen™ ALKBH4 Polyclonal Antibody
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Catalog No. PIPA562407
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100 μL
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PIPA562407 100 μL
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Catalog No. PIPA562407 Supplier Invitrogen™ Supplier No. PA562407
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: TYRFIYCSDT GWAVGTEESD FEGWAFPFPG VMLIEDFVTR EEEAELVRLM DRDPWKLSQS GRRKQDYGPK VN Highest antigen sequence identity to the following orthologs: Mouse - 79%, Rat - 79%.

Dioxygenase that mediates demethylation of actin monomethylated at 'Lys-84' (K84me1), thereby acting as a regulator of actomyosin-processes (PubMed:23673617). Demethylation of actin K84me1 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration (PubMed:23673617). In addition to proteins, also demethylates DNA: specifically demethylates DNA methylated on the 6th position of adenine (N(6)-methyladenosine) DNA, thereby regulating Polycomb silencing. [UniProt].
TRUSTED_SUSTAINABILITY

Specifications

Antigen ALKBH4
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene ALKBH4
Gene Accession No. Q9NXW9
Gene Alias 2010004B12Rik; ABH4; Abj4; alkB homolog 4, lysine demethylase; alkB homolog 4, lysine demthylase; alkB, alkylation repair homolog 4; alkB, alkylation repair homolog 4 (E. coli); Alkbh4; Alkylated DNA repair protein alkB homolog 4; alpha-ketoglutarate-dependent dioxygenase alkB homolog 4; DNA N6-methyl adenine demethylase ALKBH4; Lysine-specific demethylase ALKBH4; probable alpha-ketoglutarate-dependent dioxygenase ABH4; RGD1308608
Gene Symbols ALKBH4
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human ALKBH4. Recombinant protein control fragment (Product #RP-98508).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 54784
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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