Invitrogen™ ALKBH5 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5100873

Catalog No. PIPA5100873

Description

Antibody detects endogenous levels of total ALKBH5.

ALKBH5 (RNA demehtylase ALKBH5) is a dioxygenase that demethylates RNA by oxidative demethylation. Specifically, it demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Demethylation of m6A mRNA affects mRNA processing and export. ALKBH5 can also demethylate N(6)-methyladenosine in single-stranded DNA (in vitro). It requires molecular oxygen, alpha-ketoglutarate and iron.

Specifications

• Antigen: ALKBH5
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ALKBH5
• Gene Alias: ABH5; AlkB family member 5, RNA demethylase; alkB homolog 5, RNA demethylase; alkB, alkylation repair homolog 5; alkB, alkylation repair homolog 5 (E. coli); Alkbh5; Alkylated DNA repair protein alkB homolog 5; alpha-ketoglutarate-dependent dioxygenase alkB homolog 5; AW050020; AW215868; E130207K11; OFOXD; OFOXD1; oxoglutarate and iron-dependent oxygenase domain containing; probable alpha-ketoglutarate-dependent dioxygenase ABH5; RGD1309496; RNA demethylase ALKBH5
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 268420, 303193, 54890
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: D3ZKD3, Q3TSG4, Q6P6C2
• Gene Symbols: ALKBH5
• Immunogen: A synthesized peptide derived from human ALKBH5(Accession Q6P6C2), corresponding to amino acid residues R286-R336.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov