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Invitrogen™ ALKBH5 Polyclonal Antibody
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Catalog No. PIPA5143900
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100 μg
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Catalog No. Quantity
PIPA5143900 100 μg
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Catalog No. PIPA5143900 Supplier Invitrogen™ Supplier No. PA5143900
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Description

Rabbit Polyclonal Antibody

Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL. Positive Control - WB: human 293T whole cell, human Jurkat whole cell, human Hela whole cell, human HepG2 whole cell, human U87 whole cell. ICC/IF: A549 cell. Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

ALKBH5 (RNA demehtylase ALKBH5) is a dioxygenase that demethylates RNA by oxidative demethylation. Specifically, it demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Demethylation of m6A mRNA affects mRNA processing and export. ALKBH5 can also demethylate N(6)-methyladenosine in single-stranded DNA (in vitro). It requires molecular oxygen, alpha-ketoglutarate and iron.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ALKBH5
Applications ELISA, Western Blot, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 500 μg/mL
Conjugate Unconjugated
Formulation PBS with 4mg trehalose and no preservative
Gene ALKBH5
Gene Accession No. Q6P6C2
Gene Alias ABH5; AlkB family member 5, RNA demethylase; alkB homolog 5, RNA demethylase; alkB, alkylation repair homolog 5; alkB, alkylation repair homolog 5 (E. coli); Alkbh5; Alkylated DNA repair protein alkB homolog 5; alpha-ketoglutarate-dependent dioxygenase alkB homolog 5; AW050020; AW215868; E130207K11; OFOXD; OFOXD1; oxoglutarate and iron-dependent oxygenase domain containing; probable alpha-ketoglutarate-dependent dioxygenase ABH5; RGD1309496; RNA demethylase ALKBH5
Gene Symbols ALKBH5
Host Species Rabbit
Immunogen E.coli-derived human ALKBH5 recombinant protein (Position: E81-R180).
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 54890
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Lyophilized
Isotype IgG
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