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Invitrogen™ ALKBH5 Recombinant Rabbit Monoclonal Antibody (10H24L9)

Catalog No. 703570
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70-357-0 100 μg
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Catalog No. 70-357-0 Supplier Invitrogen™ Supplier No. 703570
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Description

Rabbit Recombinant Monoclonal Antibody

This antibody is predicted to react with Monkey, Cat, Pig. Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

ALKBH5 (RNA demehtylase ALKBH5) is a dioxygenase that demethylates RNA by oxidative demethylation. Specifically, it demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Demethylation of m6A mRNA affects mRNA processing and export. ALKBH5 can also demethylate N(6)-methyladenosine in single-stranded DNA (in vitro). It requires molecular oxygen, alpha-ketoglutarate and iron.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ALKBH5
Applications Western Blot
Classification Recombinant Monoclonal
Clone 10H24L9
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.09% sodium azide; pH 7.4
Gene ALKBH5
Gene Accession No. Q3TSG4, Q6P6C2
Gene Alias ABH5; AlkB family member 5, RNA demethylase; alkB homolog 5, RNA demethylase; alkB, alkylation repair homolog 5; alkB, alkylation repair homolog 5 (E. coli); Alkbh5; Alkylated DNA repair protein alkB homolog 5; alpha-ketoglutarate-dependent dioxygenase alkB homolog 5; AW050020; AW215868; E130207K11; OFOXD; OFOXD1; oxoglutarate and iron-dependent oxygenase domain containing; probable alpha-ketoglutarate-dependent dioxygenase ABH5; RGD1309496; RNA demethylase ALKBH5
Gene Symbols ALKBH5
Host Species Rabbit
Immunogen Protein corresponding to human ALKBH5 [aa66-aa292].
Purification Method Protein A
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 268420, 54890
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

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