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ALKBH8 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA549590

Catalog No. PA549590


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Description

Description

Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its methyltransferase domain (PubMed:20123966, PubMed:20308323). Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA (PubMed:20123966, PubMed:20308323). Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys)(PubMed:20308323). Binds tRNA and catalyzes the iron and alpha-ketoglutarate dependent hydroxylation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its dioxygenase domain, giving rise to 5-(S)-methoxycarbonylhydroxymethyluridine; has a preference for tRNA(Gly) (PubMed:21285950). Required for normal survival after DNA damage (PubMed:20308323). May inhibit apoptosis and promote cell survival and angiogenesis (PubMed:19293182).
Specifications

Specifications

ALKBH8
Polyclonal
Unconjugated
ALKBH8
Liquid
ALKBH8
KLH conjugated synthetic peptide between 494-523 amino acids from the C-terminal region of human ALKBH8.
Ammonium sulfate precipitation
RUO
Antibody
Polyclonal
Human
Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
2 mg/mL
PBS with 0.09% sodium azide
Q96BT7
Alkylated DNA repair protein alkB homolog 8, 11411-, Probable alpha-ketoglutarate-dependent dioxygenase ABH8, S-adenosyl-L-methionine-dependent tRNA methyltransferase ABH8, tRNA (carboxymethyluridine(34)-5-O)-methyltransferase ABH8, ALKBH8, ABH8
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
91801
Documents
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