ALOX5 Monoclonal Antibody (OTI2C7), TrueMAB™, OriGene

Mouse Monoclonal Antibody

Supplier:  OriGene TA807012

Catalog No. 50-168-1358

Description

The enzyme 5-lipoxygenase (5-LO) plays a key role in regulating the production of leukotrienes (LT ). Overproduction of LT contributes to several diseases, most notably chronic inflammatory diseases, including asthma, fibrosis and atherosclerosis. Recent work has demonstrated that the activity of 5-LO is regulated by PKA phosphorylation of serine-523 in 5-LO. Under normal conditions, this phosphorylation may be important in limiting inflammation. Abnormal signaling through cAMP and PKA, then, could contribute to a variety of diseases, including those characterized by chronic inflammation.

Specifications

• Antigen: ALOX5
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: P09917
• Gene Symbols: ALOX5
• Immunogen: Human recombit protein fragment corresponding to amino acids 18-364 of human ALOX5 produced in E.coli.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Western Blot
• Clone: OTI2C7
• Conjugate: Unconjugated
• Gene: ALOX5
• Gene Alias: 5-LO, 5-LOX, 5LPG, LOG5
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 240
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid