ALOX5 Mouse anti-Human, Clone: OTI1D6, lyophilized, TrueMAB™ 

Mouse Monoclonal Antibody

Manufacturer:  OriGene CF806854

Catalog No. 50-166-8009

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

The enzyme 5-lipoxygenase (5-LO) plays a key role in regulating the production of leukotrienes (LT ). Overproduction of LT contributes to several diseases, most notably chronic inflammatory diseases, including asthma, fibrosis and atherosclerosis. Recent work has demonstrated that the activity of 5-LO is regulated by PKA phosphorylation of serine-523 in 5-LO. Under normal conditions, this phosphorylation may be important in limiting inflammation. Abnormal signaling through cAMP and PKA, then, could contribute to a variety of diseases, including those characterized by chronic inflammation.

Specifications

• Antigen: ALOX5
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: ALOX5
• Format: Lyophilized
• Gene Symbols: ALOX5
• Immunogen: Human recombit protein fragment corresponding to amino acids 18-364 of human ALOX5 produced in E.coli.
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Type: Antibody
• Monoclonal or Polyclonal: Monoclonal
• Target Species: Human

• Applications: Western Blot
• Clone: OTI1D6
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: P09917
• Gene Alias: 5-LO, 5-LOX, 5LPG, LOG5
• Host Species: Mouse
• Isotype: IgG2a
• Quantity: 100 μg
• Storage Requirements: -20° C, Avoid Freeze/Thaw Cycles
• Primary or Secondary: Primary
• Gene ID (Entrez): 240