ALOX5 Mouse anti-Human, Clone: OTI2B7, lyophilized, TrueMAB
Mouse Monoclonal Antibody
Manufacturer: OriGene CF807020
Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCOThe enzyme 5-lipoxygenase (5-LO) plays a key role in regulating the production of leukotrienes (LT ). Overproduction of LT contributes to several diseases, most notably chronic inflammatory diseases, including asthma, fibrosis and atherosclerosis. Recent work has demonstrated that the activity of 5-LO is regulated by PKA phosphorylation of serine-523 in 5-LO. Under normal conditions, this phosphorylation may be important in limiting inflammation. Abnormal signaling through cAMP and PKA, then, could contribute to a variety of diseases, including those characterized by chronic inflammation.
|Human recombit protein fragment corresponding to amino acids 18-364 of human ALOX5 produced in E.coli.|
|PBS with 8% trehalose and no preservative; pH 7.3|
|5-LO, 5-LOX, 5LPG, LOG5|
|-20° C, Avoid Freeze/Thaw Cycles|
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