Invitrogen™ ALOXE3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA523953

Catalog No. PIPA523953

Description

ALOXE3 Polyclonal Antibody for Western Blot, IHC (P)

This gene is a member of the lipoxygenase family, which are catabolized by arachidonic acid-derived compounds. The encoded enzyme is a hydroperoxide isomerase that synthesizes a unique type of epoxy alcohol (8R-hydroxy-11R,12R-epoxyeicosa-5Z,9E,14Z-trienoic acid) from 12R-hydroperoxyeicosatetraenoic acid (12R-HPETE). This epoxy alcohol can activate the the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha), which is implicated in epidermal differentiation. Loss of function of the enzyme encoded by this gene results in ichthyosis, implicating the function of this gene in the differentiation of human skin. This gene is part of a cluster of lipoxygenase genes on 17p13.1. Mutations in this gene result in nonbullous congenital ichthyosiform erythroderma (NCIE). Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009].

Specifications

• Antigen: ALOXE3
• Classification: Polyclonal
• Formulation: PBS with 0.09% sodium azide; pH 7.4
• Gene Accession No.: Q9BYJ1
• Gene Symbols: ALOXE3
• Immunogen: KLH conjugated synthetic peptide between 223-252 amino acids from the central region of human ALOXE3.
• Quantity: 400 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Conjugate: Unconjugated
• Gene: ALOXE3
• Gene Alias: ALOXE3; arachidonate lipoxygenase 3; ARCI3; E-LOX; eLOX3; e-LOX-3; eLOX-3; epidermal lipoxygenase; epidermal LOX-3; Epidermis-type lipoxygenase 3; hydroperoxide isomerase ALOXE3; Hydroperoxy icosatetraenoate dehydratase
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography, Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 59344
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov