Invitrogen™ ALOXE3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA521833

Catalog No. PIPA521833

Description

Recommended positive controls: HepG2. Predicted reactivity: Mouse (84%), Rat (84%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

This gene is a member of the lipoxygenase family, which are catabolized by arachidonic acid-derived compounds. The encoded enzyme is a hydroperoxide isomerase that synthesizes a unique type of epoxy alcohol (8R-hydroxy-11R,12R-epoxyeicosa-5Z,9E,14Z-trienoic acid) from 12R-hydroperoxyeicosatetraenoic acid (12R-HPETE). This epoxy alcohol can activate the the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha), which is implicated in epidermal differentiation. Loss of function of the enzyme encoded by this gene results in ichthyosis, implicating the function of this gene in the differentiation of human skin. This gene is part of a cluster of lipoxygenase genes on 17p13.1. Mutations in this gene result in nonbullous congenital ichthyosiform erythroderma (NCIE). Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009].

Specifications

• Antigen: ALOXE3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ALOXE3
• Gene Alias: ALOXE3; arachidonate lipoxygenase 3; ARCI3; E-LOX; eLOX3; e-LOX-3; eLOX-3; epidermal lipoxygenase; epidermal LOX-3; Epidermis-type lipoxygenase 3; hydroperoxide isomerase ALOXE3; Hydroperoxy icosatetraenoate dehydratase
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 59344
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: Q9BYJ1
• Gene Symbols: ALOXE3
• Immunogen: Recombinant fragment corresponding to a region within amino acids 1 and 294 of ALOXE3 (Uniprot ID#Q9BYJ1).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov