Invitrogen™ ASZ1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA535858

Catalog No. PIPA535858

Description

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. Predicted reactivity: Mouse (83%), Rat (84%), Cat (89%), Rabbit (89%), Sheep (86%), Rhesus Monkey (97%), Chimpanzee (99%), Bovine (87%).

Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation.

Specifications

• Antigen: ASZ1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Asz1
• Gene Alias: 4933400N19Rik; ALP1; ANKL1; ankyrin repeat, SAM and basic leucine zipper domain containing 1; ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1; ankyrin-like 1; ankyrin-like protein 1; Asz1; C7orf7; CT1.19; GASZ; germ cell-specific ankyrin, SAM and basic leucine zipper domain containing protein; germ cell-specific ankyrin, SAM and basic leucine zipper domain-containing protein; Orf3
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 136991, 74068
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.77 mg/mL
• Formulation: 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: Q8VD46, Q8WWH4
• Gene Symbols: Asz1
• Immunogen: Recombinant protein encompassing a sequence within the center region of human ASZ1. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG