Invitrogen™ alpha-1 Antitrypsin Monoclonal Antibody (TMF1#4B5)

Catalog No.	Quantity
PIMA514661	100 μg

Catalog No. PIMA514661 Supplier Invitrogen™ Supplier No. MA514661

Description

Mouse Monoclonal Antibody

MA5-14661 targets Alpha1-Antitrypsin in ELISA, IP, and RIA applications and shows reactivity with Human samples. The MA5-14661 immunogen is purified human a1-Antitrypsin. MA5-14661 detects Alpha1-Antitrypsin which has a predicted molecular weight of approximately 46 kDa. Product MA514661 is a smaller package size of MIA1101 (formerly sold as a Seradyn product).

Alpha-1-AT is synthesized in the liver and it acts as an inhibitor of proteases such as trypsin, elastase, chymotrypsin, collagenase, leucocytic proteases, plasmin, and thrombin, which may be released during inflammatory reactions in the lung. In the absence of alpha-1-AT, these enzymes are not inhibited and they may digest pulmonary parenchyma. Alpha-1-AT deficiency is associated with chronic obstructive lung disease (emphysema) and less frequently with hepatic cirrhosis in infants and respiratory distress of the newborn. Increase in alpha-1-AT occurs as an acute phase response to tissue necrosis and inflammation. Serum level of alpha-1-AT is elevated in rheumatoid arthritis, bacterial infections, vasculitis, and carcinomatosis.

Specifications

• Antigen: alpha-1 Antitrypsin
• Applications: ELISA, Flow Cytometry, Immunoprecipitation, Radioimmune Assays (RIA), Western Blot
• Classification: Monoclonal
• Clone: TMF1#4B5
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1mg/mL BSA and 0.05% sodium azide; pH 7.4
• Gene: SERPINA1
• Gene Accession No.: P01009, P07758
• Gene Alias: a-1 AT; A1A; a1-antitrypsin; A1AT; AAT; Aat2; Aat-2; alpha 1 antitrypsin; alpha-1 antitrypsin; alpha-1 protease inhibitor; Alpha-1 protease inhibitor 1; alpha-1-antiproteinase; Alpha-1-antitrypsin; alpha-1-antitrypsin (protease inhibitor); alpha-1-antitrypsin 1-1; alpha-1-antitrypsin 2; alpha-1-antitrypsin null; alpha1AT; alpha-1-protease inhibitor; alpha-1-proteinase inhibitor; Digestive Zymogen; Dom1; MGC23330; MGC9222; PI; PI1; PRO0684; PRO2209; PRO2275; protease inhibitor 1 (anti-elastase), alpha-1-antitrypsin; protease inhibitor 1 (anti-elastase, antitrypsin, alpha-1); Protease Serine 1; serine (or cysteine) peptidase inhibitor, clade A, member 1A; serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1; serine (or cysteine) proteinase inhibitor, clade A (alpha-1antiproteinase, antitrypsin), member 1; serine (or cysteine) proteinase inhibitor, clade A, member 1; serine (or cysteine) proteinase inhibitor, clade A, member 1a; Serine Protease 1; serine protease inhibitor 1-1; Serine protease inhibitor A1a; serine protease inhibitor alpha 1; serine proteinase inhibitor, clade A, member 1; serpin A1; Serpin A1a; serpin family A member 1; serpin peptidase inhibitor clade A member 1; serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1; SERPINA1; Serpina1a; Short peptide from AAT; SPAAT; Spi1; Spi1-1; Spi1-3; TRP1; TRY1
• Gene Symbols: SERPINA1, Serpina1a
• Host Species: Mouse
• Immunogen: Purified human a1-Antitrypsin.
• Purification Method: Protein A
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 20700, 5265
• Target Species: Human, Mouse
• Content And Storage: Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG2a

Safety and Handling

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